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Abstract #0140

Liver R 2 * Dependence on Liver Storage Iron in Highly Iron Overloaded Patients: comparing 1.5 T to 3 T

Arthur Peter Wunderlich 1 , Steffen Klmpken 1 , Holger Cario 2 , Markus Juchems 1 , and Meinrad Beer 1

1 Dept. for Diagnostic and Interventional Radiology, Univ.-Clinic Ulm, Ulm, Germany, 2 Pediatry, Univ.-Clinic Ulm, Ulm, Germany

The liver of iron overloaded patients was scanned with breathhold multicontrast GRE sequences at 1.5 T and 3 T. To address high liver iron content (LIC) resulting in high R 2 * values we used short echo spacing resulting in out-of-phase signal for fat and water. Therefore, liver fat fraction had to be included as free parameter for data fit. Four different flip angles lead to sufficient measurement data reliably above image noise at the cost of T 1 as additional fit parameter. Data were fit to theory by Levenberg-Marquardt algorithm. Dependence of R 2 * on LIC was compared between field strengths.

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