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Abstract #0104

NODDI with dispersion anisotropy

Maira Tariq 1 , Torben Schneider 2 , Daniel C Alexander 1 , Claudia AM Wheeler-Kingshott 2 , and Hui Zhang 1

1 Department of Computer Science & Centre for Medical Image Computing, University College London, London, United Kingdom, 2 NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom

We present a clinical technique to estimate the anisotropy of the orientations distribution of neurites, using Neurite Orientation Dispersion and Density Imaging (NODDI) technique. We show that NODDI can be utilised in vivo with a more realistic description of orientations of neurites, using a clinically feasible protocol, while the NODDI technique introduced in the original publication is still an accurate model for estimating neurite density and their concentration about the dominant orientation.

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