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Abstract #0103

Resolving Myelin and Axonal Properties within the Same Voxel in Presence of Crossing Fibers by Combining Inversion Recovery and Diffusion Acquisitions

Silvia De Santis 1,2 , Daniel Barazany 1,2 , Derek K Jones 1 , and Yaniv Assaf 2

1 School of Psychology, CUBRIC, Cardiff, UK, United Kingdom, 2 Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel, Israel

The purpose of this work is to develop a new acquisition&analysis strategy, by combining inversion recovery with conventional diffusion tensor imaging, and by acquiring CHARMED protocol to calculate fiber orientations and volume fractions. For each fiber population present within a voxel, we extract a specific longitudinal relaxation time T1 by exploiting the orientational dependence of the diffusion-weighted signal that has been previously inversion-prepared. As the relaxation time T1 has been established as a solid proxy for myelination, this method effectively succeeds, for the first time, to resolve both axonal and myelin properties in presence of crossing fibers.

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