In vivo measurement of the myelin g-ratio with histological validation
Nikola Stikov 1 , Jennifer S.W. Campbell 1 , Mariette Lavalle 1 , Thomas Stroh 1 , Stephen Frey 1 , Jennifer Novek 1 , Stephen Nuara 1 , Ming-Kai Ho 1 , Barry Bedell 1 , and G. Bruce Pike 1,2
Montreal Neurological Institute, McGill
University, Montreal, QC, Canada,
Brain Institute, University of Calgary, Calgary, AB,
The myelin g-ratio, defined as the ratio between the
inner and the outer diameter of the myelin sheath, is a
fundamental property of white matter that can be
computed from a simple formula relating the myelin
volume fraction (MVF) to the fiber volume fraction (FVF).
Recent studies have suggested that the sexual dimorphism
in white matter development is due to a higher g-ratio
(thinner myelin) in adolescent boys. Additionally, in
vivo imaging of the myelin thickness in multiple
sclerosis could provide a real-time tool for tracking
myelination in lesions, facilitating the development and
evaluation of new therapeutic agents that promote
remyelination. In this abstract, a unique combination of
magnetization transfer, diffusion imaging and histology
is presented, providing a novel method for validating
of the myelin g-ratio. We show that the g-ratio computed
from MRI exhibits a high correlation with histology.
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