Abstract #0105
Imaging the microstructure of the developing cerebral cortex in the mouse embryo with diffusion MR microscopy
Manisha Aggarwal 1 , Linda J Richards 2 , and Susumu Mori 1
1
Department of Radiology, Johns Hopkins
University School of Medicine, Baltimore, MD, United
States,
2
The
Queensland Brain Institute, University of Queensland,
Brisbane, QLD, Australia
This work demonstrates diffusion MRI (dMRI) for imaging
the microstructure of the developing cerebral cortex in
the mouse embryo. 3D diffusion micro-imaging at high SNR
was achieved using accelerated diffusion-weighted
gradient and spin echo based acquisition. The resulting
dMRI data allowed resolving the microscopic structure of
transient zones in the developing cortex from embryonic
day 12 (E12) to E18 (n=3 at each stage) based on
diffusion as an endogenous probe, and revealed 3D
imaging of cortical microstructure in unprecedented
detail.
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