Abstract #0014
Mode of variation in brain structure identifies network linking protracted development, early degeneration and vulnerability to disease
Gwenaelle Douaud 1 , Adrian Groves 1 , Christian Tamnes 2 , Lars Westlye 3 , Andreas Engvig 2 , Kristine Wavhold 2 , Anthony James 4 , Achim Gass 5 , Andreas Monsch 6 , Paul Matthews 7 , Anders Fjell 2 , Stephen Smith 1 , and Heidi Johansen-Berg 1
1
FMRIB Centre, University of Oxford, Oxford,
Oxfordshire, United Kingdom,
2
Research
Group for Lifespan Changes in Brain and Cognition,
University of Oslo, Oslo, Norway,
3
KG
Jebsen Centre for Psychosis Research, Oslo University
Hospital, Oslo, Norway,
4
Department
of Psychiatry, University of Oxford, Oxfordshire, United
Kingdom,
5
Department
of Neurology, University of Heidelberg,
Baden-Wrttemberg, Germany,
6
Memory
Clinic, University Hospital Basel, Basel, Switzerland,
7
Department
of Medicine, Imperial College London, London, United
Kingdom
Although several models of brain structure link
processes of development and aging, direct evidence for
such a relationship remains elusive. Here, we show that
brain structural variation across 484 healthy
participants identifies one largely transmodal network
whose pattern of lifespan age-related change
intrinsically supports the last-in-first-out
hypothesis. We further demonstrate that this network
defines areas of heightened vulnerability for disorders
impacting the adolescent and ageing brain specifically
schizophrenia and Alzheimers. This suggests that the
spatial pattern in these disorders is not necessarily
specific to these two distinct disease processes, but
rather to their timing in disrupting healthy cerebral
development and ageing.
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