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Abstract #0013

Atlas of white-matter tracts in the human spinal cord

Marc Benhamou 1 , Vladimir Fonov 2 , Manuel Taso 3,4 , Arnaud Le Troter 3,4 , Michal Sdika 5 , Louis Collins 2 , Virginie Callot 3,4 , and Julien Cohen-Adad 1

1 Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, Quebec, Canada, 2 Montreal Neurological Institute, McGill University, Quebec, Canada, 3 Aix-Marseille Universit, CNRS, CRMBM UMR 7339, Marseille, France, 4 APHM, Hpital de la Timone, CEMEREM, Marseille, France, 5 : Universit de Lyon, CREATIS; CNRS UMR5220; Inserm U1044; INSA-Lyon; Universit Lyon 1, Lyon, France

Template-based methods offer a reliable way to conduct inter-subject studies. Building upon recent developments of a spinal cord template, this study focuses on the construction of an atlas of spinal white matter pathways. Cross-sectional drawings of Grays anatomy were manually segmented, then warped to the MNI-POLY-AMU_v1 template using symmetric diffeomorphic transformation. The atlas was then propagated between C1 and T1 vertebral levels, yielding 30 different regions of interest, taking into account partial volume effect. We demonstrate the utility of this atlas for quantifying diffusion-tensor-imaging data in five healthy volunteers. The method can be extrapolated to other multiparametric techniques.

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