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Abstract #0015

Mapping higher-order brain function and resting-state networks with diffuse optical tomography

Adam T Eggebrecht 1 , Silvina L Ferradal 2 , Amy Robichaux-Viehoever 1 , Mahlega Hassanpour 3 , Hamid Dehghani 4 , Abraham Z Snyder 5 , Tamara Hershey 6 , and Joseph P Culver 1,2

1 Radiology, Washington University School of Medicine, St. Louis, MO, United States, 2 Biomedical Engineering, Washington University School of Medicine, MO, United States, 3 Physics, Washington University School of Medicine, MO, United States, 4 School of Computer Science, University of Birmingham, United Kingdom, 5 Neurology, Washington University School of Medicine, MO, United States, 6 Psychiatry, Washington University School of Medicine, MO, United States

Mapping distributed brain function has transformed our understanding of brain function. Brain function traditionally, has been studied with positron emission tomography (PET) and with functional magnetic resonance imaging (fMRI). However, PET uses ionizing radiation, which is not permitted as an experimental procedure in children. fMRI involves exposure to strong magnetic fields and induced electric fields, which is contraindicated in patients with implanted electronic devices (e.g., deep brain stimulators, pacemakers, cochlear implants). I present herein a large field-of-view high-density diffuse optical tomography (HD-DOT) system with anatomical modeling approaches that collectively provide new imaging capabilities and enable novel milestones for optical neuroimaging.

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