The addition of a breath-hold or deep breathing task to the beginning of a resting state fMRI scan is a feasible method for cerebrovascular reactivity (CVR) mapping. However, these two tasks rely on different physiological mechanisms with different temporal properties. We used a bespoke analysis method to account for voxelwise hemodynamic lag and assessed its impact on agreement between CVR measurements from each breathing task. Good agreement was observed both across the brain and across subjects, regardless of hemodynamic lag correction, indicating both tasks are comparable options for BOLD CVR measurements in healthy subjects.
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