Abstract #3990

Quantitative susceptibility mapping in the infant brain diagnosed with congenital heart disease

Zungho Zun^1,2,3,4, Kushal Kapse¹, Nicole Andersen¹, Scott Barnett^1,2,3,4, Anushree Kapse¹, Kristina Espinosa¹, Jessica Quistorff¹, Catherine Lopez¹, Jonathan Murnick^1,3,4, Mary T. Donofrio^2,3,5, and Catherine Limperopoulos^1,2,3,4

¹Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, United States, ²Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC, United States, ³Department of Pediatrics, George Washington University, Washington, DC, United States, ⁴Department of Radiology, George Washington University, Washington, DC, United States, ⁵Division of Cardiology, Children’s National Hospital, Washington, DC, United States

Quantitative susceptibility mapping may be used to assess brain development in infants based on its ability to evaluate iron and myelin contents. We measured magnetic susceptibilities in healthy infants and those diagnosed with congenital heart disease (CHD) in the early postnatal period and investigated the associations with neurodevelopmental outcomes. We report significantly lower magnetic susceptibilities in white matter and temporal lobe of the CHD cohort and significant associations between magnetic susceptibility of the temporal lobe and Bayley-III language scores at 18 months. Our findings may suggest disturbed iron deposition in the temporal lobe can lead to delays in language development.

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