Quantitative susceptibility mapping (QSM) is known for its usefulness in imaging multiple sclerosis lesions. However, the co-occurrence of demyelination and iron accumulation due to the underlying inflammatory processes limit QSM from truthfully representing histology-like information as phase effects from positive and negative susceptibility sources within the same voxel cancel out in QSM. Here, it is shown that the separation of positive and negative susceptibility sources provides additional information to characterize susceptibility lesions.
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