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Abstract #3589

Transportable hyperpolarized glucose: protocol for sample extraction and delivery

Andrea Capozzi1, Jan Kilund2, Magnus Karlsson2, Mathilde Hauge Lerche2, and Jan Henrik Ardenkjær-Larsen2
1LIFMET, EPFL, Lausanne, Switzerland, 2Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark

Our vision is to make it possible to deliver hyperpolarized compounds to MR facilities that currently have no access to hyperpolarization technology. Today this is not the case and represents hyperpolarized-MR via dissolution Dynamic Nuclear Polarization (dDNP) main shortcoming. The reason is intrinsic in the technique and deals with the presence, in the dDNP sample, of organic free radicals necessary to generate the hyperpolarization. Herein, we demonstrate, for the first time, transportation at cryogenic temperature and remote dissolution of hyperpolarized glucose. The core idea of this project is to exploit the non-persistency of UV-induced radicals for dDNP.

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