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Abstract #3411

Normalization of Temperature Effects for Improved Quantitative Prostate Apparent Diffusion Coefficient (ADC) Imaging Across Multiple Sites

Ken-Pin Hwang1, R. Jason Stafford2, Joshua Yung2, and Aradhana M. Venkatesan3
1The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States, 2Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States, 3Department of Abdominal Radiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, United States

Performing a standardized measurement of ADC requires maintaining a phantom temperature of 0oC. To expand quality assurance of ADC measurement on a network of scanners at room temperatures, a model for temperature dependence was applied as a correction factor. A diffusion phantom was scanned on 1.5T and 3T scanners at four locations using sequence parameters from a prostate protocol. With temperature of the phantom measured at each acquisition, ADC measurements on identically configured scanners exhibited reduced variance when normalized to modeled values. The use of the temperature model is potentially useful in developing a QA program for ADC measurements.

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