Abstract #3062

BUDA-SAGE with unsupervised denoising enables fast, distortion-free, high-resolution T2, T2*, iron and myelin susceptibility mapping

Zijing Zhang^1,2, Long Wang³, Hyeong-Geol Shin⁴, Jaejin Cho², Tae Hyung Kim², Jongho Lee⁴, Jinmin Xu¹, Tao Zhang³, Huafeng Liu¹, and Berkin Bilgic²

¹State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, ²Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts general hospital, Boston, MA, United States, ³Subtle Medical Inc, Menlo Park, CA, United States, ⁴Laboratory for Imaging Science and Technology (LIST), Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of

We propose BUDA-SAGE, an efficient echo‐planar imaging (EPI) sequence for quantitative mapping. The acquisition includes multiple T₂^*-, T₂^’- and T₂-weighted contrasts. We alternate the phase-encoding polarities across the shots in this multi-shot navigator-free acquisition to eliminate geometric distortion. An unsupervised Self2Self (S2S) neural network (NN) was utilized to perform denoising after BUDA reconstruction to achieve 1×1×2 mm³ resolution with high SNR. We demonstrate the ability of BUDA-SAGE to provide whole-brain, distortion-free, high-resolution multi-contrast images and quantitative T₂, T₂^* maps in 50 seconds, and separate para- and dia-magnetic susceptibility maps in 140 seconds.

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