Abstract #3061

Mapping correlation spectra of T1 and mean diffusivity in the human brain

Alexandru V Avram^1,2, Joelle E Sarlls³, and Peter J Basser¹

¹Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States, ²Center for Neuroscience and Regenerative Medicine, The Henry Jackson Foundation, Bethesda,, MD, United States, ³National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

We develop a novel clinical pulse sequence with integrated inversion recovery (IR) and isotropic diffusion encoding (IDE) preparations for mapping correlation spectra of subvoxel T1 and mean diffusivities (MD) from measurements acquired with a wide range of joint T1-MD weightings. We evaluated the performance of the pulse sequence and spectral reconstruction pipeline using data from numerical simulations, a calibrated MRI phantom and healthy volunteers. Preliminary results suggest that maps of subvoxel T1-MD spectra show tissue-specific components in the human brain. Quantifying the heterogeneity of T1-diffusion properties in microscopic water pools could improve biological specificity in many clinical applications.

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