Abstract #3028

Automated Magnetic Resonance Parkinsonism Index: Test-Retest Reliability and 10 Year Changes in Aging and Parkinson’s Disease

Yao-Chia Shih^1,2, Bénédicte Maréchal^3,4,5, Ricardo Corredor Jerez^3,4,5, Septian Hartono^2,6, Hui-Hua Li^2,7, Isabel Hui Min Chew¹, Eng King Tan^2,6, and Ling Ling Chan^1,2

¹Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁵LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁶Department of Neurology, National Neuroscience Institute (Outram-campus), Singapore, Singapore, ⁷Health Services Research Unit, Singapore General Hospital, Singapore, Singapore

Progressive supranuclear palsy phenotypes are increasingly recognized and the Magnetic Resonance Parkinsonism Index (MRPI) useful in supporting clinical diagnosis. We examined the test-retest reliability of a landmark-based automated algorithm to derive MRPI from >2000 brain scans across different cohorts with neurodegeneration and MRI systems. We also investigated temporal changes in the MRPI derived from longitudinal scans 6–10 years apart in 53 subjects from case-control Parkinson’s disease cohorts. We found the automated MRPI fast (averaging 25s ± 2s per case) and reliable (average coefficient of variance <20%), without significant change in MRPI over time in aging and Parkinson’s disease.

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