Different functional connectivities of Basal nucleus of Meynert (BNM-FC) and the other brain regions among patients with Parkinson’s Disease (PD) accompanied and not accompanied with mild cognition impairment (PD-MCIs and PD-NCs, respectively) have been investigated in this study. A model based on Support-Vector-Machine with BNM-FC and neuropsychological results showed significantly decreased BNM-FC in the right superior parietal lobe of PD-MCIs than PD-NCs, allowing an accurate differentiation between PD-MCIs and PD-NCls. These results advanced our knowledge of the cholinergic system underpinning cognitive function in PD individuals.
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