The stimulus duration depended nonlinearity of the BOLD response is difficult to model, as it often requires stimulus-specific parameter values. Here we have extended an existing framework of BOLD response modeling based on biophysical simulations of realistic microvascular anatomy and dynamics to incorporate viscoelastic properties of individual blood vessels and tissue. We then applied this model to examine BOLD response nonlinearities to long-duration stimuli. We find that this model largely captures the differences in BOLD responses observed to short- and long-duration stimuli.
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