Neuroimaging studies in humans showed different patterns of BOLD responses in cerebellar vermis and cortical regions when performing tasks at different grip forces. In this study we investigated the basis of different cerebellar fMRI responses ex-vivo. Capillary dilation and neuronal activity were recorded in the vermis and hemisphere of mouse cerebellar slices, highlighting a region and frequency dependency of neurovascular responses in the granular layer. The correlation between neuronal activity and vessel diameter changes was explored through a computational model, which supported a central role played by the NMDAR-NO pathway in shaping the vasodilation time course.
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