Ultrashort-T2 signal from white matter can be captured for imaging using dedicated short-T2 techniques. In this work, such methods were applied to D2O-exchanged human brain tissue from four donors diagnosed with multiple sclerosis to obtain 0.39 mm isotropic resolution MR images of the ultrashort-T2 tissue components and a lower-resolution multi-TE image series which, via a model fitting procedure, was used to produce maps of the relative content of myelin lipid-protein bilayer. As proof-of-principle, the contrast in these images was compared with corresponding myelin-stained cryosections and sample photographs, yielding promising correlation for white matter, grey matter and multiple sclerosis lesions.
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