There is a general lack of agreed-upon guidelines regarding the DWI sequences to use, particularly to optimize the microstructural characterization of lesions. We evaluated the effects of demyelination and axonal loss on DKI and NODDI metrics and the impact of the sequence on the sensitivity to damage by performing a Monte-Carlo diffusion simulation inside a novel model of damaged WM. The sequence strongly affected the means and sensitivities of the metrics. Consequently, comparing DKI and NODDI analysis employing different sequences could lead to erroneous conclusions regarding the damage assessment: further investigations are needed for a community consensus on acquisition details.
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