Abstract #2245

Accounting for Measurement Noise in a Multi-Site Newborn Diffusion Weighted Imaging Study

Jerod M Rasmussen¹, Alice M Graham², Pathik D Wadhwa¹, Sonja Entringer³, Martin Styner⁴, Beatriz Luna⁵, Thomas G O'Connor⁶, Damien A Fair⁷, and Claudia Buss³

¹UC Irvine, Irvine, CA, United States, ²Oregon Health Sciences University, Portland, OR, United States, ³Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁴University of North Carolina, Chapel Hill, NC, United States, ⁵University of Pittsburgh, Pittsburgh, PA, United States, ⁶University of Rochester, Rochester, NY, United States, ⁷University of Minnesota, Minneapolis, MN, United States

We leverage an exemplar relationship (FA_WM vs. postmenstrual age [PMA]) to quantify the benefits conferred by adjustment for QC measures in a multi-site infant DWI study. Data was preprocessed using a common pipeline (dHCP) and the FA_WM-PMA association tested without and with controlling for SNR, CNR and mean FD. All three QC measures were broadly associated with FA_WM within sites. Within and across sites, inclusion of QC measures greatly increased FA_WM variance explained by PMA. Accounting for QC measures results in an improved capability for identifying reproducible small-effect size relationships in large multi-site infant imaging studies.

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