Abstract #2059

Can Diffusion Kurtosis Imaging and 3D-Arterial Spin Labeling perfusion imaging improve the diagnostic accuracy of Binswanger's Disease?

Xiaoyi He^1,2, Weiqiang Dou³, Hansen Schie¹, and Junying Wang^1,2

¹Department of Medical Imaging, Shandong Provincial Qianfishan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jinan, China, ²Shandong First Medical University, Taian, China, ³GE Healthcare, MR Research China, Beijing, China

This study aimed to investigate whether the combined 3D-arterial spin labeling (3D-ASL) and diffusion kurtosis imaging (DKI) can distinguish Binswanger’s disease (BD) patients from healthy subjects. 35 BD patients and 33 age/gender-matched controls were scanned in DKI and ASL at 3T. Compared with healthy subjects, significant alterations were found in almost all DKI & ASL relevant parameters on the major lesions and partial non-lesion regions of BD. With these findings, we thus proved that the combined DKI and 3D-ASL can be effectively tools exploring pathophysiological mechanisms and performing robust diagnostic accuracy for BD patients.

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