Abstract #1846

Cross-Vendor Test-Retest Analysis of 3D pCASL Cerebral Blood Flow

Kay Jann¹, Xingfeng Shao¹, Samantha J Ma^1,2, Karl G Helmer³, Michael Magaletta³, Mitchell J Horn⁴, Andrew D Warren⁴, Vanessa A Gonzalez⁴, Hanzhang Lu⁵, Yang Li⁵, Zixuan Lin⁵, Kaisha Hazel⁵, George Pottanat⁵, and Danny JJ Wang¹

¹Laboratory of Functional MRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, United States, ²Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, ³Department of Radiology, Massachusetts General Hospital and Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA, United States, ⁴Department of Neurology, Massachusetts General Hospital and Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA, United States, ⁵The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Standardized acquisition protocols have been recommended for Arterial Spin Labeling perfusion MRI across major MRI platforms. However, there are still vendor and sequence specific differences for ASL implementations that limit the use of ASL for clinical trials. Here we evaluated the repeatability of CBF measurements across 4 different MR platforms on a traveling cohort of 10 volunteers using standardized 3D background suppressed pCASL sequences. We show that while there are differences in global CBF values, relative CBF values are reproducible in major vascular territories across the 4 MRI platforms.

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