Single Loop Tri-frequency Surface Coil Design for 1H MRI and Interleaved Dynamic 2H and 17O MRS Applications at Ultrahigh Field of 16.4T

To capture anatomical information and dynamic changes of different metabolic activities in the brain or other organs using a singular RF coil, we developed a loop RF surface coil design with a wide tune-match isolation and active tune circuitry for proton ( ¹H) MRI, and interleaved deuterium ( ²H) and oxygen ( ¹⁷O) MRS measurements at 16.4T. We obtained static ¹H MRI and performed interleaved dynamic ²H and ¹⁷O measurements in phantom studies. Results showed proficient proton imaging and quasi-stable ²H and ¹⁷O signals with rapid acquisition, indicating the potential of the design for robust high temporal resolution metabolic and anatomical imaging applications.