Abstract #1739

Feasibility of Single Breath-hold Isotropic Voxel 129Xe MRI in COVID-19 Survivors using a Key-Hole Method.

Tuneesh K. Ranota¹, Hacene Serrai², David G. McCormack³, Grace Parraga^1,4,5, and Alexei Ouriadov^1,2,6

¹School of Biomedical Engineering, Faculty of Engineering, The University of Western Ontario, London, ON, Canada, ²Department of Physics and Astronomy, The University of Western Ontario, London, ON, Canada, ³Division of Respirology, Department of Medicine, The University of Western Ontario, London, ON, Canada, ⁴Robarts Research Institute, London, ON, Canada, ⁵Department of Medical Biophysics, The University of Western Ontario, London, ON, Canada, ⁶Lawson Health Research Institute, London, ON, Canada

Hyperpolarized ¹²⁹Xe gas lung MRI is an efficient technique used to investigate and assess pulmonary diseases. To improve the performance of ¹²⁹Xe MRI in lung imaging a method for high-resolution 3D static ventilation images using FGRE combined with the key-hole method in a single breath-hold, was proposed. This technique acquires high-resolution ¹²⁹Xe 3D static ventilation isotropic-voxel images from the COVID-19 survivors in a single breath-hold. The SNR of the images allowed for the analysis of VDP. This study confirms the feasibility of using isotropic-voxel acquisition sequence in a single breath-hold MRI to study the effects of COVID-19 on the lungs.

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