Abstract #1316

ACcelerated Echo-train shifted EPTI (ACE-EPTI) for fast distortion-blurring-free high-resolution diffusion imaging with minimal echo time

Zijing Dong^1,2, Fuyixue Wang^1,3, Lawrence L. Wald^1,3, and Kawin Setsompop^4,5

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, ³Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, ⁴Department of Radiology, Stanford University, Stanford, CA, United States, ⁵Department of Electrical Engineering, Stanford University, Stanford, CA, United States

ACcelerated Echo-train shifted EPTI (ACE-EPTI) is proposed for fast and high-fidelity dMRI and diffusion-relaxometry. Distortion- and blurring-free imaging at high resolution is achieved using the time-resolved imaging approach, which recovers sharp multi-contrast images at each echotime across a continuous readout window. A new spatiotemporal encoding is proposed for rapid acquisition, requiring only 3 shots for submillimeter imaging with the capability of self-navigated physiological phase correction. An echo-training shifting acquisition is also incorporated into ACE-EPTI to enable shortest possible TE, which provides 30-40% higher SNR-efficiency over single-shot EPI. High-quality diffusion images and diffusion-weighted quantitative maps acquired by ACE-EPTI are demonstrated in-vivo.

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