A functional biomarker of age-related cognitive decline is yet to be elucidated but would be desirable to better understand detrimental and protective processes in order to promote cognitive health for the elderly. Challenges arise from multiple sources of variance across individuals and within brain perfusion maps with an unknown link between local or network function and clinical tests of global cognition. Principal Component Analysis provides the opportunity to address some of these knowledge gaps, by defining this relationship and relating this to underlying anatomical regions.
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