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Abstract #1225

A pilot study of socially deprivated brain alterations using fMRI and dMRI in domestic dogs

Xueru Liu1,2, Huilin Hong3, Zhentao Zuo1,2,4, Hui Zhao3, Rui Tian3, Yongqing Zhang2,3,4, and Yan Zhuo1,2,4
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, BeiJing, China, 2University of Chinese Academy of Sciences, Beijing, China, 3State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China, 4CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China

Social interactions, like sleep, is the basic needs for humans and animals, its neural mechanism is not fully understood. Domestic dog has similar emotional and social processing with humans, it would be a promising animal model for social interaction. In this study, 3 beagles were social deprived (SD) 4-week, and performed resting-state fMRI and diffusion MRI. The functional connectivity and diffusion metrics were compared between SD and wild type dogs. We found the functional connectivity strengthened within prefrontal cortex and weakened between prefrontal cortex with visual and auditory cortex in SD. Demyelination observed in frontal, temporal, and insula regions.

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