Abstract #1199

Evaluation of cellular sensitivity for magnetic particle imaging and fluorine-19 magnetic resonance imaging

Olivia C Sehl^1,2 and Paula J Foster^1,2

¹Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, University of Western Ontario, London, ON, Canada

Fluorine-19 (¹⁹F) MRI and magnetic particle imaging (MPI) are both quantitative modalities used for cell tracking. We evaluated the cellular sensitivity of MPI using ferucarbotran on a preclinical MPI system and ¹⁹F MRI using perfluorocarbons on a 3 Tesla clinical system. For both modalities, significant linear increases in ¹⁹F and MPI signal were detected with increasing number of mesenchymal stem cells (MSC). As few as 4000 MSC were reliably detected with MPI and 256 x 10³ MSC with ¹⁹F MRI using the same scan time (1.5 minutes/cell pellet). Both of these detection limits were improved with longer imaging times.

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