The purpose of this study is to assess the accuracy of Gadolinium-based contrast agent (GBCA) concentration measured using the novel DCE-MRI method with two flip angles, without using the pre-contrast T1 measurement. The accuracy of the proposed method was assessed using the conventional approach with pre-contrast T1 measurement as well as the Gd concentration measurement using Inductively coupled plasma-mass spectrometry using the blood samples collected at the end of each scan. The results exhibited a strong correlation and agreement between the Gd concentration from the proposed two flip angle method and those from the conventional MRI method and ICP-MS analysis.
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