Abstract #1194

Multiparametric MRI of Renal Tissue Shows Dietary Differences Between Survivors and Non-survivors in Sepsis-associated Acute Kidney Injury

Wan-Ting Zhao^1,2,3, Karl-Heinz Herrmann¹, Martin Krämer¹, Renat Sibgatulin¹, Ali Nahardani^1,2, Jürgen R. Reichenbach¹, and Verena Hoerr^1,2,4

¹Medical Physics Group,Institute of Diagnostic and Interventional Radiology, University Hospital Jena, Jena, Germany, ²Center for Sepsis Control and Care, University Hospital Jena, Jena, Germany, ³Institute of Medical Microbiology, University Hospital Jena, Jena, Germany, ⁴Clinic for Radiology, University Hospital Muenster, Muenster, Germany

Acute kidney injury (AKI) is a highly lethal complication of sepsis that is frequently asymptomatic with versatile physiological alterations. As diet has gain recognition in the regulation of immune response, we aim to investigate the dietary impact on the course and outcome of sepsis by multiparametric MRI using perfusion, as well as T1 and T2 relaxation time. Cortical T1 and T2 relaxation time was found to differ significantly in animals having received protein-rich diet compared to healthy controls. By combining the cortical T2 relaxation time with perfusion, additional information could be gained, which allowed to distinguish between non-survivors and survivors.

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