Deuterium metabolic imaging (DMI) is a new method to map abnormal metabolism of tumors. bSSFP might provide high SNR for DMI, due to the high T2/T1 ratios of the injected deuterated glucose, and the lactate, which arises from abnormal metabolism. We developed a linear-combination balanced SSFP method for spectrally resolving glucose, lactate and water, using predicted signal evolutions for different bSSFP phase-cyclings. Our method was able to generate images of the individual compounds in phantoms and in vivo.
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