Abstract #0764

Improving Multiparametric MR - TRUS Guided Fusion Prostate Biopsies with Hyperpolarized 13C Pyruvate Metabolic Imaging : Technical Development

Hsin-Yu Chen¹, Robert A. Bok¹, Hao G. Nguyen², Katsuto Shinohara², Antonio C. Westphalen¹, Zhen J. Wang¹, Michael A. Ohliger¹, Lucas Carvajal¹, Jeremy W. Gordon¹, Peder E.Z. Larson¹, Rahul Aggarwal², John Kurhanewicz¹, and Daniel B. Vigneron¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States

This project developed a new approach of integrating research biopsy targets, defined by metabolic abnormalities on hyperpolarized (HP) ¹³C pyruvate MRI, into clinical multiparametric MRI workflow to guide software-fusion transrectal ultrasound (TRUS) biopsy for improved prostate cancer risk stratification. Feasibility was investigated in 3 prostate cancer patient studies, for which research biopsy targets corresponding to high pyruvate-to-lactate conversion rates (k_PL) were identified and outlined by experienced abdominal radiologists. Fusion biopsies identified histologically-confirmed cancer at two out of three “C13” targets, consistent with clinically low- to intermediate-risk disease, supporting continued active surveillance management for these patients.

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