Abstract #0763

Hyperpolarized 13C MR imaging of prostate cancer patient derived xenograft models and their response to therapy

Shubhangi Agarwal¹, Jinny Sun¹, Emilie Decavel-Bueff¹, Robert A Bok¹, Romelyn Delos Santos¹, Mark Van Criekinge¹, Rahul Aggarwal², Daniel B Vigneron¹, Donna Peehl¹, John Kurhanewicz¹, and Renuka Sriram¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²2Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States

This study demonstrates for the first time, a successful study of three small cell neuroendocrine prostate cancer patient derived xenografts (PDX) models in liver and bone in pre-clinical setting. Kidney served as an optimum site for propagation with its rich blood supply and high take rate. Hyperpolarized ¹³C MRI was able to identify metabolic differences between kidney, bone and liver tumors. The same PDXs had different metabolism when implanted in bone and liver. Hyperpolarized [1-¹³C] pyruvate conversion to lactate may be used to indicate early response to carboplatin in small cell neuroendocrine prostate cancer models in the bone.

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