Despite its high relevance in metabolic research, the non-invasive measurement of adipocyte size remains an unmet need. DW-MRS has been previously applied to probe diffusion restriction effects in vivo to measure lipid droplets in animals up to diameters of 10 µm and in humans up to diameters of 50 µm. However, DW-MRS suffers from signal loss due to intravoxel-dephasing even when minimal motion is present. This work proposes a novel DW-MRI sequence and diffusion signal processing. In simulations and ex vivo adipose tissue measurements, the presented method results show agreement with ground truth and histology in measuring lipid droplet size.
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