Abstract #0573

Evolutionary gap of the default mode network organization between non-hominid primates and humans

Clément M. Garin¹, Yuki Hori², Stefan Everling ^2,3, Christopher T. Whitlow ⁴, Finnegan J. Calabro ⁵, Beatriz Luna⁵, Marc Dhenain ^6,7, and Christos Constantinidis ^1,8

¹Neurobiology and Anatomy, Wake Forest University, Winston Salem, NC, United States, ²Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, ON, Canada, ³Department of Physiology and Pharmacology, The University of Western Ontario, London, ON, Canada, ⁴Department of Radiology, Section of Neuroradiology, Wake Forest University, Winston Salem, NC, United States, ⁵Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States, ⁶Neurodegenerative Diseases Laboratory, Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay UMR 9199, Fontenay-aux-Roses, France, ⁷Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, Fontenay-aux-Roses, France, ⁸Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

We performed cross-species comparison to determine how the human default mode network (DMN) connectivity pattern compares to non-hominid primates. We characterized and compared the resting-state network functional organisation in humans, macaques, marmosets, and mouse lemurs using functional and anatomical atlases. We found decreased engagement of mPFC (medial prefrontal cortex) in all non-hominid primates “DMN-like” compared to humans. Another network involving mPFC was identified in all non-hominid primates but not in humans. Altogether, our results show that high order networks often assumed to be shared across primates diverge considerably between non-hominid species and humans.

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