Abstract #0433

Sensitive imaging schemes for dynamic glucose enhanced (DGE) MRI to detect glucose uptake and clearance in mouse brain at 3T

Jianpan Huang¹, Joseph H. C. Lai¹, Xiongqi Han¹, Zilin Chen¹, Yang Liu¹, Peng Xiao¹, Lin Chen^2,3, Jiadi Xu^2,3, and Kannie W. Y. Chan^1,3,4

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴City University of Hong Kong Shenzhen Research Institute, Shenzhen, China

We developed a high-sensitivity dynamic glucose enhanced (DGE) MRI acquisition and post-processing scheme for sensitive monitoring glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF) at 3T. By investigating Carr-Purcell-Meiboom-Gill sequence (CPMG), on-resonance variable delay multi-pulse (onVDMP) and on-resonance spin-locking (onSL), a high-sensitivity DGE MRI scheme composed of CPMG method for monitoring parenchyma and onVDMP method for monitoring CSF was proposed. We incorporated the multilinear singular value decomposition (MLSVD) based denoising method in post-processing, which enables the detection of DGE signals from the brain parenchyma and CSF at low concentration of D-glucose (12.5% w/w) injection.

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