Resting state fMRI mapping in the mouse is typically carried out under light anesthesia, preventing a full characterization of how the ensuing functional architecture compares to awake conditions. Leveraging a novel protocol for fMRI connectivity mapping in awake mice, we provide a fine-grained description of the network structure and dynamic organization of brain-wide functional connectivity in this species. Notably, by comparing network features across brain states, we identify a robust set of state-dependent network changes, including a distinctive dynamic signature of consciousness. These results open the way to the implementation of awake rsfMRI in the mouse.
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