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Abstract #0355

Regional changes in brain development and cognitive outcome in infants with Congenital Heart Disease

Alexandra F Bonthrone1, Ralica Dimitrova1,2, Andrew Chew1, Christopher J Kelly1, Lucilio Cordero-Grande1,3, Olivia Carney1, Alexia Egloff1, Emer Hughes1, Katy Vecchiato1,2, John Simpson4, Joseph V Hajnal1,5, Kuberan Pushparajah4, Suresh Victor1, Chiara Nosarti1,6, Mary A Rutherford1, A. David Edwards1, Jonathan O’Muircheartaigh1,2, and Serena J Counsell1
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, 3Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid and CIBER-BBN, Madrid, Spain, 4Paediatric Cardiology Department, Evelina London Children's Healthcare, London, United Kingdom, 5Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 6Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom

Infants with Congenital Heart Disease (CHD) are at high risk of neurodevelopmental disorders. We acquired presurgical neonatal T2-weighted MRI (N=66), cerebral oxygen delivery (CDO2; N=53), and 22-month cognitive and motor scores (N=44). Atypicality indices, representing the degree of deviation of a regional brain volume from the normative neonatal mean for a given gestational age, sex and postnatal age, were calculated. Reduced CDO2 was indirectly associated with lower cognitive scores through the mediating effect of negative bilateral caudate and thalami atypicality indices. The aetiology of cognitive impairments in CHD may encompass poor CDO2 leading to impaired caudate and thalamus growth.

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