Decreased cerebral metabolism has been implicated in pathogenesis of Alzehimer’s disease. The endothelial nitric oxide synthase (eNOS) pathway plays a major role in cerebral blood flow regulation. This study used DSC-MRI in 10 patients treated with a drug regimen for supporting the eNOS pathway to investigate how perfusion patterns were associated with treatment response based on clinical psychometrics. Regional analysis on rCBF maps showed significant signal changes in the cognitively improved cohort based on ADAS-cog scores while patients that showed cognitive deterioration or no change based on ADAS-cog scores did not show significant rCBF changes.
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