Abstract #0200

Reductions of fibre-specific white matter metrics in autism are determined by the level of intellectual functioning: a fixel-based analysis

Chun-Hung Yeh^1,2, Rung-Yu Tseng¹, Susan Shur-Fen Gau³, and Hsiang-Yuan Lin⁴

¹Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan, ²Department of Child and Adolescent Psychiatry, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan, ³Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ⁴Azrieli Adult Neurodevelopmental Centre and Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada

Based on the multi-band multi-shell diffusion MRI data acquisition and fixel-based analysis, the purpose of our study is to provide more insights into neurobiological accounts of autism, inclusive of understudied low functioning individuals. Preprocessed DWI data of 38 TD and 65 autistic participants were analysed. We found reduced fibre density in the splenium of the corpus callosum in autisitic individuals. This autism-associated alteration appears to be mainly driven by those autistic individuals with developmental disabilities. Our findings suggest studies inclusive of autistic people comorbid with developmental disabilities using the novel models may bridge some heterogeneity noted in the literature.

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