Abstract #0078

Fluorine Magnetic Resonance Imaging for Natural Killer Cell Tracking with a Dual Tuned 1H/19F Torso Coil at 3T

Paul Begovatz¹, Lawrence Lechuga¹, Monica Cho², Mallery Olsen², Rachel McMahon³, David Vail^3,4, and Sean Fain^1,5,6

¹Medical Physics, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ²Pediatrics, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ³Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁴Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States, ⁵Radiology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ⁶Biomedical Engineering, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States

Fluorine magnetic resonance imaging (19F-MRI) has been demonstrated as a non-invasive method to track and quantify immune cells in vivo. However due to the low ¹⁹F spin density of immune cell labeling, these studies have been mostly conducted on ultra-high field MRI systems, or with small sensitive surface coils at clinical field strengths. This feasibility study found that concentrations of perfluoropolyether (PFPE), and phantoms consisting of fewer than one million PFPE labeled NK cells were reliably detected through ¹⁹F-MRI with the combination of a cartesian 3D fast spin echo imaging sequence, and a dual tuned 1H/19F torso coil at 3T.

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