Abstract #0077

CEST-MRI guided sequential drug delivery using injectable hydrogel for local treatment in the brain

Xiongqi Han¹, Jianpan Huang¹, and Kannie Wai Yan Chan^1,2,3

¹Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, ²Biomedical Engineering, Shenzhen Research Institute, City University of Hong Kong, Shenzhen, China, ³Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Glioblastoma (GBM) is the most malignant brain tumor with notorious heterogeneous, infiltrative and chemoresistance. Here, we developed a hydrogel-based drug delivery system for sequential and sustainable local drug delivery with rheological properties that favor applications to the brain. We designed methotrexate (MTX) to release prior to gemcitabine (Gem). Using CEST, the multicomponent of hydrogel matrix could be detected at 3 T, including the contrast of loaded drugs (5.4%) at 2.2-2.4 ppm and liposomal hydrogel matrix at -3.6 ppm in vitro. Furthermore, it showed combined cytotoxicity on U87 cells, demonstrating its potential on CEST MRI guided local treatment.

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