Abstract #0022

Effect of doxorubicin treatment on myocardial metabolism in patients with breast cancer

Jae Mo Park^1,2,3, Galen D Reed⁴, Jeff Liticker¹, William C Putnam⁵, Alvin Chandra^6,7, Katarina Yaros⁶, Aneela Afzal^1,6, James MacNamara⁶, Ronald G Hall⁵, Crystal E Harrison¹, Alagar Muthukumar⁶, Colby Ayers⁶, James de Lemos⁶, Craig R Malloy^1,6, Hsiao-Ching Li^6,7, Barbara Haley^6,7, and Vlad G Zaha^1,6

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Electrical and Computer Engineering, University of Texas at Dallas, Richardson, TX, United States, ⁴GE Healthcare, Dallas, TX, United States, ⁵Pharmacy Practice, Texas Tech University, Dallas, TX, United States, ⁶Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁷Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

This study evaluates the feasibility of hyperpolarized 13C MRS for detection of early metabolic response in the myocardium of patients after anthracycline treatment. Patients with breast cancer were studied using hyperpolarized [1-13C]pyruvate before and after doxorubicin. Appearance of [13C]bicarbonate was significantly decreased after doxorubicin compared to the baseline exam while no change in [1-13C]lactate was detected. The reproducibility of hyperpolarized exams was examined by two injections of hyperpolarized [1-13C]pyruvate. The study demonstrates that hyperpolarized 13C spectra of the heart are sensitive to early injury of the mitochondria after doxorubicin therapy in patients with breast cancer in a reproducible manner.

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