q-Space imaging (QSI) was compared against conventional DWI and non-Gaussian diffusion models of diffusion kurtosis imaging (DKI) and stretched-exponential model (SEM) to evaluate the skewness in histogram distribution of diffusion displacement and diffusivity for profiling breast tumour cellularity. We investigated whole breast tumours excised from surgery, with imaging performed same day overnight on a clinical 3T MRI system. We found QSI to yield a higher effect gradient to assess cellularity in breast cancer compared with conventional diffusion-weighted imaging methods. The skewness obtained from QSI further showed fidelity with the skewness of cellularity obtained from histology.
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