The cortical representation of hand motor function, hand knob region, is localized in the precentral gyrus. We found that the age-related rapid development of hand knob areas peaks at 4-5 years, and the left side increases faster than right. And the different increase rate between the left and right hand knob regions of normal children may be related to dominant hemisphere of handedness. This study will help to understand the process of hand function development in children and provide the research basis for the study of the upper limb pathway of the nerve center.
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