Functional connectivity strength (FCS) differences are investigated in term neonates with congenital heart disease (CHD) as compared to normal controls. In CHD neonates, FCS is reduced in default mode network (DMN), salience network (SN), and central executive network (CEN) regions. However, widespread positive post-conceptional age (PCA) at birth – X – CHD interactions were found, indicating this effect is more pronounced for CHD neonates born earlier in gestation, and that prolonged in utero exposure may be beneficial for development of brain functional connectivity. Negative correlations of nasal nitric oxide (nNO) and FCS were also found, suggesting a partly vascular etiology.
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