Abstract #4599

Depicting White Matter Developmental Trajectory Using Diffusional Kurtosis Imaging：from neonate through childhood

Yuli Zhang¹, Xianjun Li¹, Mengxuan Li¹, Qinli Sun¹, Miaomiao Wang¹, Chao Jin¹, Congcong Liu¹, Fan Wu¹, Xiaoyu Wang¹, Huifang Zhao¹, Yannan Chen¹, Cong Tian¹, Peiyao Chen¹, Xiaocheng Wei², and Jian Yang¹

¹the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China, ²2. MR Research China, GE Healthcare, Xi'an, China, China

Brain development is a complex process linked with behavioral, emotional, cognitive, especially the maturation process of WM is both of great scientific and clinical importance¹. However, the lack of continuous development of WM from neonate to childhood. Diffusion kurtosis imaging(DKI)is a diffuse imaging method that reflects non-Gaussian distribution information of biological water. This study aimed to use DKI parameters depicting developmental trajectory of WM. The fractional anisotropy(FA), mean kurtosis(MK),axial kurtosis(AK),radial kurtosis(RK)positively correlated with age; the axial diffusivity(AD) radial diffusivity(RD) negativly correlated with age. These parameters changed rapidly before the age of 2 years old, and then gradually slowed down.

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