Abstract #4598

CHemotherapy-Induced cardiotoxicity: LongitudinaL imaging study (CHILL)

Nivedita K. Naresh¹, Doaa Aly², Michal Schafer², Brian Fonseca³, Bruce Landeck², Jenna Sopfe⁴, Lorna P Browne¹, and Alex J Barker^1,5

¹Radiology, Children's Hospital Colorado, Aurora, CO, United States, ²Cardiology, Children's Hospital Colorado, Aurora, CO, United States, ³Pediatrics, Children's Hospital Colorado, Aurora, CO, United States, ⁴Oncology, Children's Hospital Colorado, Aurora, CO, United States, ⁵Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, United States

In this retrospective study, we explored the potential of cardiac MRI to identify functional imaging biomarkers of cardiotoxicity in pediatric patients exposed to anthracycline chemotherapy. Global and regional myocardial strain was reduced in patients with ejection fraction (EF)>50% indicating that myocardial strain may be an early imaging biomarker of cardiotoxicity in pediatric patients. Additionally, regional differences were found in strain measurements in this population. The results from this study will be used to perform prospective imaging studies to identify early functional imaging biomarkers of cardiotoxicity in pediatric population.

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